Description

trans-2-(o-Tolyl)Cyclopropan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclopropane ring structure. This compound is critical for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking a reliable, high-quality building block for complex synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclopropane geometry.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up API synthesis under Good Manufacturing Practice (GMP) conditions.
• Reference Standard: Employed as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	trans-2-(o-Tolyl)Cyclopropan-1-Amine Hydrochloride
CAS No.	1820572-17-5
Molecular Formula	C10H14ClN
Molecular Weight	183.68 g/mol
Synonyms	trans-2-(2-Methylphenyl)cyclopropanamine hydrochloride; (1R,2S)-rel-2-(2-Methylphenyl)cyclopropanamine hydrochloride; 2-(o-Tolyl)cyclopropanamine hydrochloride, trans-; o-Tolylcyclopropylamine hydrochloride; 2-Methylbenzenecyclopropanamine hydrochloride; 1-Cyclopropyl-2-methylbenzeneamine hydrochloride; (1S,2R)-2-(2-Methylphenyl)cyclopropan-1-amine hydrochloride
EINECS	Contact for details

Quality Control

Our trans-2-(o-Tolyl)Cyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.