Description

trans-2-(4-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a cyclopropane carboxylic acid core with a difluoromethoxy phenyl substituent. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific stereochemistry and fluorinated motifs. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing next-generation small molecule drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel APIs, especially in metabolic disease, CNS, and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, where the difluoromethoxy group can enhance biological activity and environmental stability.
• Chemical Biology Research: Serves as a versatile probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Material Science Precursor: Potential use in synthesizing specialized monomers or ligands for advanced polymeric materials and catalysts.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for custom synthesis projects requiring high-purity, complex organic intermediates.

Basic Information

Item	Details
Product Name	trans-2-(4-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid
CAS No.	1820569-50-3
Molecular Formula	C11H10F2O3
Molecular Weight	228.19 g/mol
Synonyms	trans-2-[4-(Difluoromethoxy)phenyl]cyclopropanecarboxylic acid; (1R,2S)-rel-2-[4-(Difluoromethoxy)phenyl]cyclopropanecarboxylic acid; 2-(4-(Difluoromethoxy)phenyl)cyclopropanecarboxylic acid (trans); 4-(Difluoromethoxy)benzenepropanoic acid, α,β-cyclopropane-; DFM-CPA; (trans)-2-(4-(Difluoromethoxyphenyl))cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of trans-2-(4-(Difluoromethoxy)Phenyl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including a Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles to ensure it meets the stringent requirements for pharmaceutical R&D. Our quality protocols are designed to support compliance with cGMP and ICH guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its chemical nature, the material should be kept away from strong acids and organic solvents. Keep the container tightly sealed when not in use to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.