Description

3-Phenylbicyclo[1.1.1]pentan-1-amine hydrobromide is a high-purity, advanced pharmaceutical intermediate featuring a unique and highly strained [1.1.1]propellane core structure. This compound is of significant value for medicinal chemistry research and development, enabling the exploration of novel chemical space and the synthesis of three-dimensional drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, particularly in areas like central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs) with enhanced three-dimensional properties.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to introduce the rigid, sp3-rich bicyclo[1.1.1]pentane (BCP) scaffold as a bioisostere for aromatic rings or tert-butyl groups.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component in linker design for bifunctional molecules due to its defined geometry and stability.
• Chemical Biology Probes: Employed in the creation of tool compounds for target validation and mechanistic studies in biological systems.
• Agrochemical Research: Potential intermediate for developing new crop protection agents with novel modes of action.
• Material Science: Exploration of its use as a monomer or cross-linker for creating polymers with unique mechanical properties.

Basic Information

Product Name	3-Phenylbicyclo[1.1.1]pentan-1-amine hydrobromide
CAS No.	1818847-90-3
Molecular Formula	C11H14N·HBr
Molecular Weight	226.15 g/mol
Synonyms	3-Phenylbicyclo[1.1.1]pentan-1-amine HBr; 3-Phenyl-BCP-NH2·HBr; 1-Amino-3-phenylbicyclo[1.1.1]pentane hydrobromide; BCP-NH2·HBr (Phenyl substituted); 3-Phenyl-[1.1.1]propellane-1-amine hydrobromide; 3-Phenyl-1-aminobicyclo[1.1.1]pentane HBr salt; (3-Phenylbicyclo[1.1.1]pentan-1-yl)amine hydrobromide
EINECS	Contact for details

Quality Control

Our 3-Phenylbicyclo[1.1.1]pentan-1-amine HBr is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive pharmaceutical R&D applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development with custom synthesis and analytical method development to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.