Description

trans-2-Aminocyclobutane-1-Carboxylic Acid Hydrochloride is a high-purity, pharmaceutically relevant building block featuring a constrained cyclobutane ring system. This compound is of significant interest in medicinal chemistry for the development of novel peptide mimetics and bioactive molecules due to its rigid, three-dimensional structure. It serves as a critical intermediate for researchers and manufacturers in pharmaceutical R&D, particularly for creating conformationally restricted analogs and probing structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, including protease inhibitors and receptor modulators.
• Peptidomimetics Research: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and biological activity.
• Chemical Biology Probes: Employed in the development of tool compounds for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Synthesis: Potential intermediate for creating advanced active ingredients with unique steric properties.
• Academic & Discovery Chemistry: Serves as a specialized starting material for method development and library synthesis in medicinal chemistry programs.

Basic Information

Product Name	trans-2-Aminocyclobutane-1-Carboxylic Acid Hydrochloride
CAS No.	1818847-78-7
Molecular Formula	C5H10ClNO2
Molecular Weight	151.59 g/mol
Synonyms	(1R,2S)-2-Aminocyclobutane-1-carboxylic acid hydrochloride; (1S,2R)-2-Aminocyclobutane-1-carboxylic acid hydrochloride; trans-2-ACBC HCl; trans-2-Aminocyclobutanecarboxylic acid hydrochloride; Cyclobutane-1-carboxylic acid, 2-amino-, hydrochloride, (1R,2S)-rel-; 2-Aminocyclobutanecarboxylic Acid Hydrochloride (trans); ACC hydrochloride
EINECS	Contact for details

Quality Control

Our trans-2-Aminocyclobutane-1-Carboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (trans isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.