Description

4-((3-Chloro-2,4-Difluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol CAS NO 1818217-55-8 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazoline class of compounds. This compound is a critical building block in the synthesis of targeted kinase inhibitors, offering significant value in modern drug discovery and development pipelines. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in producing novel oncology and therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of tyrosine kinase inhibitors (TKIs) for targeted cancer therapies.
• Oncology Drug Research: Used in the research and development of novel small-molecule drugs targeting specific cancer pathways.
• Biochemical Research: Serves as a reference standard and a tool compound in enzymatic and cellular assays to study kinase activity and inhibition.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create complex molecules with potential biological activity.
• API Development: Utilized in the process development and scale-up of Active Pharmaceutical Ingredients (APIs) for clinical trials and commercial manufacturing.

Basic Information

Product Name	4-((3-Chloro-2,4-Difluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol
CAS No.	1818217-55-8
Molecular Formula	C15H10ClF2N3O2
Molecular Weight	337.71 g/mol
Synonyms	4-((3-Chloro-2,4-difluorophenyl)amino)-7-methoxyquinazolin-6-ol; 7-Methoxy-4-[(3-chloro-2,4-difluorophenyl)amino]quinazolin-6-ol; 4-[(3-Chloro-2,4-difluorophenyl)amino]-7-methoxy-6-quinazolinol; 6-Quinazolinol, 4-[(3-chloro-2,4-difluorophenyl)amino]-7-methoxy-; Kinase Inhibitor Intermediate 1818217-55-8
EINECS	Contact for details

Quality Control

Our 4-((3-Chloro-2,4-Difluorophenyl)Amino)-7-Methoxyquinazolin-6-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.