Description

Pyrene-PEG4-Acid is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a pyrene fluorophore and a terminal carboxylic acid group. This bifunctional compound is engineered to serve as a critical building block for advanced bioconjugation and materials science applications, offering both fluorescent labeling capabilities and a reactive site for covalent attachment. It is essential for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay design, and advanced polymer synthesis who require precise, reliable, and customizable linker molecules.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Linkers: Used to attach cytotoxic drugs, imaging agents, or other payloads to antibodies, proteins, or peptides via its carboxylic acid group, with the pyrene moiety enabling fluorescence-based tracking.
• Fluorescent Labeling and Probes: Serves as a versatile fluorescent tag for biomolecules (nucleic acids, proteins) and nanoparticles due to pyrene's strong, environmentally-sensitive emission.
• Polymer and Materials Functionalization: Acts as a functional monomer or end-group modifier to introduce fluorescence and reactive acid sites into PEG-based hydrogels, dendrimers, and other polymeric materials.
• Diagnostic Reagent Development: Incorporated into the design of fluorescent sensors, lateral flow assays, and other diagnostic tools where a stable, bright fluorophore with a linker is required.
• Surface Modification and Immobilization: Utilized to create functionalized surfaces on chips, beads, or electrodes for biosensing applications, leveraging the carboxylic acid for covalent coupling.
• Click Chemistry and Crosslinking: The terminal acid group can be further derivatized to participate in click chemistry reactions (e.g., with NHS esters) for creating complex, multifunctional architectures.

Basic Information

Item	Details
Product Name	Pyrene-PEG4-Acid
CAS No.	1817735-34-4
Molecular Formula	C33H40O8
Molecular Weight	564.67 g/mol
Synonyms	1-Pyrenebutanoic acid, ω-hydroxy-3,6,9,12-tetraoxatetradec-1-yl ester; Pyrene-PEG4-COOH; 4-(Pyren-1-yl)butanoic acid-PEG4-acid; Pyrene-PEG4-propionic acid; Pyrene tetraethylene glycol carboxylic acid; PEG4-Pyrene-acid; Pyrene-(CH2)3COO-PEG4-COOH; Pyrene butyric acid-PEG4-acid
EINECS	Contact for details

Quality Control

Our Pyrene-PEG4-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with key parameters including assay (HPLC), impurity profile, and functional group verification. Our quality commitment supports applications requiring GMP-grade materials for preclinical and diagnostic development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. For short-term use, the product may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Functional Group Assay (Acid Titration)	95 - 105% of theoretical

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.