Description

(Sp-4-1)-[1,3-Bis[2,6-Bis(1-Propylbutyl)Phenyl]-4,5-Dichloro-1,3-Dihydro-2H-Imidazol-2-Ylidene]Dichloro(3-Chloropyridine-κn)-Palladium is a highly specialized, third-generation N-heterocyclic carbene (NHC) palladium precatalyst designed for superior performance in demanding cross-coupling reactions. This compound matters because it offers exceptional thermal stability, high activity at low catalyst loadings, and excellent functional group tolerance, directly addressing the need for efficient and scalable synthetic methodologies. It is an essential tool for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require robust and reliable catalysts for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: Enabling key carbon-carbon and carbon-heteroatom bond formations (e.g., Suzuki-Miyaura, Buchwald-Hartwig, Negishi couplings) in the production of active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Facilitating the synthesis of novel herbicides, fungicides, and insecticides through efficient cross-coupling of heterocyclic and sterically hindered substrates.
• Advanced Material Fabrication: Catalyzing polymerization reactions and the synthesis of conjugated organic molecules for use in OLEDs, semiconductors, and organic photovoltaics.
• Process Chemistry & Scale-Up: Ideal for transitioning from lab-scale discovery to pilot plant and manufacturing due to its stability and predictable performance under various conditions.
• Methodology Development in Academia: A catalyst of choice for developing new synthetic transformations and exploring challenging bond constructions in academic and industrial R&D laboratories.
• Fine Chemical Production: Used in the synthesis of complex, high-value specialty chemicals, flavors, and fragrances where precision and selectivity are paramount.

Basic Information

Item	Details
Product Name	(Sp-4-1)-[1,3-Bis[2,6-Bis(1-Propylbutyl)Phenyl]-4,5-Dichloro-1,3-Dihydro-2H-Imidazol-2-Ylidene]Dichloro(3-Chloropyridine-κn)-Palladium
CAS No.	1814936-54-3
Molecular Formula	C52H70Cl4N3Pd
Molecular Weight	1000.28 g/mol
Synonyms	Palladium PEPPSI-IPentCl Precatalyst; PEPPSI-IPent(Cl) Pd Catalyst; Dichloro(3-chloropyridine)[1,3-bis(2,6-bis(1-propylbutyl)phenyl)-4,5-dichloro-imidazol-2-ylidene]palladium(II); Pd-PEPPSI-IPentCl; Third-Generation PEPPSI Catalyst; NHC-Pd(II) 3-Cl-Py Complex; IPentCl-Pd-Py Catalyst; (SP-4-1)-Dichloro1,3-bis[2,6-bis(1-propylbutyl)phenyl]-4,5-dichloro-2,3-dihydro-1H-imidazol-2-ylidene-κC2palladium
EINECS	Contact for details

Quality Control

Every batch of our (Sp-4-1)-[1,3-Bis[2,6-Bis(1-Propylbutyl)Phenyl]-4,5-Dichloro-1,3-Dihydro-2H-Imidazol-2-Ylidene]Dichloro(3-Chloropyridine-κn)-Palladium is synthesized and handled under inert atmosphere to preserve its catalytic activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and performance-relevant metrics are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a dry, freezer-safe environment. This compound is easily oxidized and hygroscopic; prolonged exposure to air, moisture, or ambient temperature will degrade its catalytic performance. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Pd Content (ICP-OES)	10.5 - 10.8 %
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.