Description

(R)-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine Hydrochloride is a high-purity chiral amine building block essential for advanced pharmaceutical research and development. This compound serves as a critical intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by medicinal chemists and process development scientists in pharmaceutical and biotechnology companies for creating novel therapeutic candidates. The compound's defined stereochemistry and fluorinated tetrahydronaphthalene scaffold make it a valuable asset for structure-activity relationship (SAR) studies and the development of potent, selective drug molecules.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• CNS Drug Development: A critical precursor in the research of therapeutics for neurological and psychiatric conditions.
• Process Chemistry & Scale-up: Serves as a starting material or intermediate in the development of scalable, GMP-compliant synthetic routes.
• Asymmetric Synthesis: Employed as a chiral amine synthon in the construction of complex, enantiomerically pure molecules.
• Reference Standard: Used as an analytical standard for quality control and method development in API manufacturing.

Basic Information

Item	Details
Product Name	(R)-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine Hydrochloride
CAS No.	1810074-60-2
Molecular Formula	C10H13FN • HCl
Molecular Weight	201.68 g/mol (Free base: 165.22 g/mol)
Synonyms	(1R)-5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; (R)-5-Fluoro-1,2,3,4-tetrahydronaphthalen-1-amine HCl; (R)-5-Fluoro-1-amino-1,2,3,4-tetrahydronaphthalene hydrochloride; (R)-5-Fluoro-1-tetralinamine hydrochloride; (R)-1-Amino-5-fluoro-1,2,3,4-tetrahydronaphthalene hydrochloride; 5-Fluoro-(1R)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride; (R)-5-Fluoro-α-tetralinamine hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-5-Fluoro-1,2,3,4-Tetrahydronaphthalen-1-Amine Hydrochloride is manufactured under strict quality control protocols to ensure high chemical and chiral purity suitable for research and development applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, enantiomeric excess, and impurity profiles. We are committed to supplying material that meets the stringent requirements of pharmaceutical R&D, with specifications available to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.