Description

5-(Trifluoromethoxy)-2,3-Dihydro-1H-Isoindole Hydrochloride is a high-purity advanced pharmaceutical intermediate (API intermediate) featuring a unique trifluoromethoxy-substituted isoindoline scaffold. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new drug candidates, particularly in the areas of central nervous system (CNS) and metabolic disorder therapeutics.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Synthesis: Used in the construction of complex molecules targeting various protease enzymes.
• Ligand Development: Employed in the synthesis of specialized ligands for receptor binding studies and diagnostic applications.
• Agrochemical Research: Potential intermediate for developing new crop protection agents and herbicides.
• Material Science: Can be utilized in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	5-(Trifluoromethoxy)-2,3-Dihydro-1H-Isoindole Hydrochloride
CAS No.	1810070-26-8
Molecular Formula	C9H9ClF3NO
Molecular Weight	239.62 g/mol
Synonyms	5-(Trifluoromethoxy)isoindoline hydrochloride; 2,3-Dihydro-5-(trifluoromethoxy)-1H-isoindole hydrochloride; 1H-Isoindole, 2,3-dihydro-5-(trifluoromethoxy)-, hydrochloride; 5-(Trifluoromethoxy)isoindoline HCl; 5-Trifluoromethoxyisoindoline hydrochloride; 5-(Trifluoromethoxy)-2,3-dihydro-1H-isoindole HCl; 1810070-26-8
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethoxy)-2,3-Dihydro-1H-Isoindole Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our commitment to cGMP principles and ISO-aligned processes guarantees a reliable supply of high-quality material for critical R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.