Description

[3-(Aminomethyl)Oxetan-3-Yl]Methanol Hydrochloride CAS NO 1810070-02-0 is a high-value, functionalized oxetane building block with a primary amine group protected as its hydrochloride salt. This compound is critical for medicinal chemistry and advanced materials research, offering a rigid, polar scaffold that can significantly influence the physicochemical properties of target molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs), prodrugs, and specialized polymers.

Application

• Pharmaceutical Intermediate: Key building block for introducing the constrained, polar oxetane moiety into drug candidates to modulate solubility, metabolic stability, and bioavailability.
• Proteolysis Targeting Chimera (PROTAC) Linker: Serves as a component in the design of bifunctional molecules, connecting E3 ligase ligands to target protein binders.
• Bioconjugation & ADC Development: The amine functionality allows for conjugation to antibodies, peptides, or payloads in antibody-drug conjugate (ADC) research.
• Polymer & Material Science: Monomer for synthesizing specialty polymers with unique thermal and mechanical properties for high-performance coatings and resins.
• Agrochemical Synthesis: Intermediate in the development of new generation herbicides and fungicides with improved environmental profiles.
• Ligand & Catalyst Design: Precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	[3-(Aminomethyl)Oxetan-3-Yl]Methanol Hydrochloride
CAS No.	1810070-02-0
Molecular Formula	C5H12ClNO2
Molecular Weight	153.61 g/mol
Synonyms	3-(Aminomethyl)-3-(hydroxymethyl)oxetane hydrochloride; (3-Hydroxymethyloxetan-3-yl)methylamine hydrochloride; 3-(Aminomethyl)-3-oxetanemethanol hydrochloride; Oxetane-3,3-dimethanamine hydrochloride; 3-(Hydroxymethyl)-3-(aminomethyl)oxetane HCl; 3-Oxetanemethanol, 3-(aminomethyl)-, hydrochloride; Aminomethyl-oxetan-3-yl-methanol HCl
EINECS	Contact for details

Quality Control

Our [3-(Aminomethyl)Oxetan-3-Yl]Methanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for water content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.