Description

(R)-(+)-7-[n-(2-Phenylthio)Ethylamino]-7'-[Bis(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane CAS NO 1809609-39-9 is a sophisticated chiral phosphine ligand designed for high-performance asymmetric catalysis. This compound is critical for enabling precise stereochemical control in complex synthetic transformations, directly impacting the yield and purity of advanced pharmaceutical intermediates. It is an essential material for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-purity ligands to develop efficient and sustainable synthetic routes.

Application

• Asymmetric Hydrogenation: A key ligand for the enantioselective reduction of prochiral olefins, ketones, and imines in pharmaceutical API synthesis.
• Cross-Coupling Reactions: Facilitates challenging C-C and C-X bond formations under mild conditions with high enantioselectivity.
• Process Chemistry Development: Used in the scale-up and optimization of manufacturing processes for chiral drugs and agrochemicals.
• Academic & Industrial R&D: A valuable tool for exploring new catalytic methodologies and synthesizing novel chiral compounds.
• Catalyst Library Screening: Employed in high-throughput screening to identify optimal catalytic systems for specific transformations.

Basic Information

Product Name	(R)-(+)-7-[n-(2-Phenylthio)Ethylamino]-7'-[Bis(3,5-Dimethylphenyl)Phosphino]-2,2',3,3'-Tetrahydro-1,1'-Spirobindane
CAS No.	1809609-39-9
Molecular Formula	C47H48NPS2
Molecular Weight	722.00 g/mol
Synonyms	(R)-SpiroBIPHEP-Thioethylamine Ligand; (R)-7-(2-(Phenylthio)ethylamino)-7'-bis(3,5-dimethylphenyl)phosphino-2,2',3,3'-tetrahydro-1,1'-spirobiindane; (R)-DTBM-SpiroBIPHEP-Thioethylamine; Chiral Spiro Phosphine-Amine Ligand; Asymmetric Hydrogenation Ligand CAS 1809609-39-9; (R)-(+)-SpiroBIPHEP-NH(CH2)2SC6H5 Ligand
EINECS	Contact for details

Quality Control

Every batch of this high-value ligand is produced and tested under strict quality management systems. We guarantee high chemical and chiral purity through comprehensive analytical techniques including HPLC, NMR, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and specific rotation. Our quality commitment ensures batch-to-batch consistency for reliable performance in your critical catalytic applications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. Allow the container to reach room temperature in a dry environment before opening to minimize moisture exposure.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Specific Rotation [α]D20	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.