Description

cis-3-Phenylcyclobutan-1-Amine Hydrochloride is a high-purity, pharmaceutically relevant building block offered as a stable hydrochloride salt. This compound matters as a versatile chiral intermediate critical for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals, enabling research and development in advanced therapeutic areas. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries seeking to incorporate the rigid, three-dimensional cyclobutane scaffold into new molecular entities.

Application

• Pharmaceutical Intermediate: Key chiral building block for the research and synthesis of potential new drug candidates, particularly in central nervous system (CNS) and metabolic disorder therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and library synthesis to explore novel bioactive compounds.
• Agrochemical Synthesis: Intermediate in the development of new generation pesticides and herbicides that require specific stereochemistry.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric catalysis.
• Fine Chemical Production: Employed in the multi-step synthesis of complex, high-value specialty chemicals.
• Academic & Institutional R&D: Used in universities and research institutes for methodological studies and the exploration of new chemical spaces.

Basic Information

Product Name	cis-3-Phenylcyclobutan-1-Amine Hydrochloride
CAS No.	1807916-62-6
Molecular Formula	C10H14ClN
Molecular Weight	183.68 g/mol
Synonyms	(1r,3s)-3-Phenylcyclobutan-1-amine hydrochloride; (1R,3S)-3-Phenylcyclobutan-1-amine HCl; cis-3-Phenylcyclobutanamine hydrochloride; 3-Phenylcyclobutan-1-amine hydrochloride (cis-); 1-Amino-3-phenylcyclobutane hydrochloride (cis-); (1S,3R)-3-Phenylcyclobutan-1-amine hydrochloride; (1S,3R)-1-Amino-3-phenylcyclobutane hydrochloride; 1807916-62-6
EINECS	Contact for details

Quality Control

Our cis-3-Phenylcyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (cis-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.