Description

Boc-Aminoxy-Peg3-Otbu is a specialized bifunctional polyethylene glycol (PEG) linker featuring orthogonal protecting groups. This compound is engineered to facilitate the controlled conjugation and bioconjugation of molecules, offering a defined spacer arm length and solubility enhancement. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced therapeutics, including antibody-drug conjugates (ADCs) and peptide-based drugs. The product is supplied under strict quality control to ensure batch-to-batch consistency for sensitive synthetic applications.

Application

• Bioconjugation Linker: A key building block for the site-specific conjugation of payloads (e.g., drugs, dyes, toxins) to proteins, antibodies, or peptides.
• ADC (Antibody-Drug Conjugate) Development: Used to create stable, cleavable, or non-cleavable linkers that connect cytotoxic agents to monoclonal antibodies.
• PEGylation Reagent: Employed to introduce polyethylene glycol chains onto bioactive molecules to improve pharmacokinetics, solubility, and stability.
• Proteomics & Chemical Biology: Facilitates the synthesis of activity-based probes and tools for studying protein function and interactions.
• Material Science & Surface Modification: Serves as a functional spacer for modifying surfaces, nanoparticles, or hydrogels with bioactive ligands.
• Solid-Phase Peptide Synthesis (SPPS): Used as a handle or building block for introducing PEG spacers and orthogonal functionalities into synthetic peptides.

Basic Information

Product Name	Boc-Aminoxy-Peg3-Otbu
CAS No.	1807512-44-2
Molecular Formula	C20H39NO8
Molecular Weight	421.53 g/mol
Synonyms	1-tert-Butyl 14-(1,1-dimethylethyl) 4,7,10-trioxa-2,13-diazatetradecanedioate; 2,5,8,11-Tetraoxatetradecanedioic acid, 14-[(1,1-dimethylethoxy)amino]-13-oxo-4,7,10-trioxa-2-azatetradecan-1-oic acid 1,14-bis(1,1-dimethylethyl) ester; tert-Butyl (14-(tert-butoxy)-3,6,9,12-tetraoxa-15-azapentadecan-15-yloxy)carbamate; Boc-NH-PEG3-Otbu; Boc-aminoxy-PEG3-acid tert-butyl ester; Aminooxy-PEG3-t-butyl ester Boc protected
EINECS	Contact for details

Quality Control

Our Boc-Aminoxy-Peg3-Otbu is manufactured under a quality management system and undergoes rigorous analytical testing to ensure high purity and consistency. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development and cGMP-grade manufacturing needs, with specifications tailored to your application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.