Description

5-Bromo-2-Fluoro-3-Hydroxybenzotrifluoride is a high-value, multi-functional fluorinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring bromo, fluoro, hydroxy, and trifluoromethyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry for creating novel drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Chemical Research & Development: Employed in academic and industrial R&D for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce complex functionalities.
• Fluorine Chemistry: An important reagent for studying structure-activity relationships (SAR) and for the incorporation of fluorine atoms into target molecules to modulate lipophilicity, metabolic stability, and binding affinity.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-Hydroxybenzotrifluoride
CAS No.	1807191-85-0
Molecular Formula	C7H3BrF4O
Molecular Weight	258.99 g/mol
Synonyms	3-Bromo-6-Fluoro-2-Hydroxybenzotrifluoride; 2-Hydroxy-3-bromo-6-fluoro-α,α,α-trifluorotoluene; 5-Bromo-2-fluoro-3-(trifluoromethyl)phenol; 5-Bromo-2-fluoro-α,α,α-trifluoro-m-cresol; 2-Fluoro-5-bromo-3-hydroxybenzotrifluoride; 1807191-85-0; Benzotrifluoride, 5-bromo-2-fluoro-3-hydroxy-
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Fluoro-3-Hydroxybenzotrifluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) specifying identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment to guarantee reproducible results and supply chain reliability for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.