Description

1-Bromo-2-Difluoromethoxy-5-Fluoro-3-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring bromo, difluoromethoxy, fluoro, and nitro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, particularly in medicinal chemistry for lead optimization and the development of fluorinated drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), especially in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where the difluoromethoxy and fluorine groups enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as fluorinated polymers or small molecules for OLEDs and semiconductors.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluorine groups provide sites for selective substitution with various nucleophiles, enabling diverse molecular diversification.
• Ligand and Catalyst Development: Employed in the synthesis of specialized fluorinated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	1-Bromo-2-Difluoromethoxy-5-Fluoro-3-Nitrobenzene
CAS No.	1805591-69-8
Molecular Formula	C7H3BrF3NO3
Molecular Weight	293.00 g/mol
Synonyms	2-Bromo-1-difluoromethoxy-4-fluoro-5-nitrobenzene; 3-Bromo-4-difluoromethoxy-1-fluoro-2-nitrobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-5-fluoro-3-nitro-; 5-Flu-oro-2-(difluoromethoxy)-3-nitrobenzyl bromide (related); BDFNB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Difluoromethoxy-5-Fluoro-3-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.