Description

4-Bromo-3-Cyano-2-(Trifluoromethyl)Aniline is a high-value, multi-functional aromatic amine building block characterized by its bromo, cyano, and trifluoromethyl substituents. This unique combination of functional groups makes it a critical intermediate for the synthesis of complex molecules, offering significant advantages in modulating electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of advanced materials and dyes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Manufacturing: Acts as an intermediate for producing high-performance, light-fast dyes and pigments.
• Chemical Research & Development: A versatile reagent for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and further functionalization in academic and industrial R&D settings.
• Fluorinated Compound Library: Essential for constructing diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4-Bromo-3-Cyano-2-(Trifluoromethyl)Aniline
CAS No.	1805250-35-4
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	2-Amino-4-bromo-3-cyano-α,α,α-trifluorotoluene; 4-Bromo-3-cyano-2-(trifluoromethyl)benzenamine; 2-(Trifluoromethyl)-4-bromo-3-aminobenzonitrile; 4-Bromo-3-cyano-α,α,α-trifluoro-o-toluidine; 2-Amino-4-bromo-α,α,α-trifluoro-m-tolunitrile; Benzenamine, 4-bromo-3-cyano-2-(trifluoromethyl)-; 4-Bromo-3-cyano-2-trifluoromethylaniline
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Cyano-2-(Trifluoromethyl)Aniline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.