Description

3-Bromo-5-Fluoro-2-Iodophenol is a highly functionalized halogenated phenol derivative, serving as a critical multi-purpose building block in advanced organic synthesis. Its unique combination of bromine, fluorine, and iodine substituents on the phenolic ring offers versatile sites for selective cross-coupling and further functionalization. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated phenols.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its halogen-rich structure.
• Cross-Coupling Reactions: Essential substrate for Suzuki, Stille, and Sonogashira coupling reactions, where the iodine and bromine atoms act as orthogonal leaving groups.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing novel chelating ligands and organocatalysts.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological systems and diagnostic applications.

Basic Information

Product Name	3-Bromo-5-Fluoro-2-Iodophenol
CAS No.	1804910-88-0
Molecular Formula	C6H3BrFIO
Molecular Weight	316.90 g/mol
Synonyms	2-Iodo-3-bromo-5-fluorophenol; 3-Bromo-5-fluoro-2-iodo-phenol; Phenol, 3-bromo-5-fluoro-2-iodo-; 5-Fluoro-3-bromo-2-iodophenol; 2-Hydroxy-6-bromo-4-fluoro-1-iodobenzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-5-Fluoro-2-Iodophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and GC-MS, confirming compliance with customer specifications and industry best practices.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive nature and tendency to be easily oxidized, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.