Description

1-Bromo-2-Chloro-3-Fluoro-4-Nitrobenzene is a high-purity, multi-halogenated aromatic building block of significant importance in advanced organic synthesis. Its precise substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogen and nitro groups are leveraged for bioactivity.
• Material Science Research: Acts as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where halogen and nitro groups influence color and stability.
• Cross-Coupling Reactions: A valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to introduce complex aryl groups.
• Chemical Library Development: Used in high-throughput screening and combinatorial chemistry to generate diverse compound libraries for drug discovery.

Basic Information

Product Name	1-Bromo-2-Chloro-3-Fluoro-4-Nitrobenzene
CAS No.	1804382-22-6
Molecular Formula	C6H2BrClFNO2
Molecular Weight	254.44 g/mol
Synonyms	2-Bromo-1-Chloro-6-Fluoro-3-Nitrobenzene; 4-Nitro-1-Bromo-2-Chloro-3-Fluorobenzene; Benzene, 1-bromo-2-chloro-3-fluoro-4-nitro-; BCFNB
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Chloro-3-Fluoro-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, GC, and NMR to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and regulated production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.