Description

(3-Fluoroazetidin-3-yl)methanol hydrochloride is a high-value, fluorinated azetidine building block essential for modern medicinal chemistry and drug discovery. This compound matters as a key chiral intermediate for introducing the 3-fluoroazetidine-3-methanol pharmacophore, a motif sought after for its ability to modulate the physicochemical and metabolic properties of bioactive molecules. Pharmaceutical R&D and fine chemical synthesis teams need it for the development of novel therapeutics, particularly in areas like kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for targeted cancer therapies and kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore the impact of the fluorinated azetidine moiety on potency, selectivity, and metabolic stability.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Chemical Biology Probes: Incorporation into tool compounds for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and niche target molecules.
• Library Synthesis: Used in the generation of diverse compound libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Item	Detail
Product Name	(3-Fluoroazetidin-3-yl)methanol Hydrochloride
CAS No.	1803604-98-9
Molecular Formula	C4H9ClFNO
Molecular Weight	141.57 g/mol
Synonyms	3-(Hydroxymethyl)-3-fluoroazetidine hydrochloride; (3-Fluoro-3-azetidinyl)methanol hydrochloride; 3-Fluoroazetidine-3-methanol hydrochloride; 3-Fluoro-3-(hydroxymethyl)azetidine HCl; 3-Fluoro-azetidin-3-yl-methanol hydrochloride; Azetidine, 3-fluoro-3-(hydroxymethyl)-, hydrochloride; 3-Fluoro-3-azetidinemethanol hydrochloride
EINECS	Contact for details

Quality Control

Our (3-Fluoroazetidin-3-yl)methanol hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture uptake and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.