Description

1-(Difluoromethyl)Cyclopropan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane scaffold with a difluoromethyl amine moiety. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the cyclopropane and fluorine motifs for improved drug-like properties.
• Agrochemical Synthesis: Serves as a precursor in the development of novel pesticides and herbicides, leveraging the stability of the cyclopropane ring.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Fine Chemical Production: Used in custom synthesis and contract manufacturing for high-value, complex organic molecules.
• Bioconjugation and Probe Synthesis: The amine hydrochloride salt is a reactive handle for creating biochemical probes and diagnostic agents.

Basic Information

Product Name	1-(Difluoromethyl)Cyclopropan-1-Amine Hydrochloride
CAS No.	1803595-15-4
Molecular Formula	C4H8ClF2N
Molecular Weight	143.56 g/mol
Synonyms	1-(Difluoromethyl)cyclopropanamine hydrochloride; 1-Amino-1-(difluoromethyl)cyclopropane hydrochloride; Cyclopropanamine, 1-(difluoromethyl)-, hydrochloride; 1-(Difluoromethyl)cyclopropan-1-amine HCl; (1-(Difluoromethyl)cyclopropyl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)Cyclopropan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.