Description

1-(Difluoromethyl)Cyclohexan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique difluoromethylated cyclohexylamine scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules where fluorine substitution is used to modulate pharmacokinetic properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for central nervous system (CNS) targets and metabolic diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of the difluoromethyl group on potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Serves as a precursor for developing novel active ingredients with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Utilized in the creation of chiral amines and ligands for asymmetric synthesis.
• Chemical Biology Probes: Incorporated into tool compounds for investigating biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex amine derivatives.

Basic Information

Product Name	1-(Difluoromethyl)Cyclohexan-1-Amine Hydrochloride
CAS No.	1803592-79-1
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	1-(Difluoromethyl)cyclohexanamine hydrochloride; 1-Amino-1-(difluoromethyl)cyclohexane hydrochloride; Cyclohexanamine, 1-(difluoromethyl)-, hydrochloride (1:1); 1-(Difluoromethyl)cyclohexylamine HCl; α-(Difluoromethyl)cyclohexylamine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(Difluoromethyl)Cyclohexan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for advanced research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.