Description

3-Fluoro-3-(Trifluoromethyl)Azetidine Hydrochloride is a high-value, multi-fluorinated azetidine building block essential for modern medicinal chemistry and agrochemical research. Its unique structure, featuring a fluorinated quaternary carbon, makes it a critical intermediate for introducing conformational rigidity and modulating the physicochemical properties of target molecules. This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers developing novel bioactive compounds, including potential therapeutics and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disease research.
• Agrochemical Research: Used in developing advanced herbicides, fungicides, and insecticides where the fluorinated azetidine moiety enhances bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Incorporated into advanced polymers and specialty materials to impart unique fluorochemical properties such as hydrophobicity and chemical resistance.
• PET Tracer Synthesis: Potential utility as a building block for Positron Emission Tomography (PET) imaging agents due to the presence of fluorine atoms.
• Chemical Biology Probes: Used to create molecular probes for studying enzyme function and protein-ligand interactions.

Basic Information

Product Name	3-Fluoro-3-(Trifluoromethyl)Azetidine Hydrochloride
CAS No.	1803588-53-5
Molecular Formula	C4H6ClF4N
Molecular Weight	179.54 g/mol
Synonyms	3-Fluoro-3-(trifluoromethyl)azetidine HCl; 3-Fluoro-3-(trifluoromethyl)azetidine hydrochloride; 1-Azabicyclo[1.1.0]butane, 3-fluoro-3-(trifluoromethyl)-, hydrochloride; 3-Fluoro-3-trifluoromethylazetidine hydrochloride; 3-Fluoro-3-(trifluoromethyl)azetidine monohydrochloride; Azetidine, 3-fluoro-3-(trifluoromethyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-3-(Trifluoromethyl)Azetidine Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and MS analysis. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.