Description

3-(Difluoromethyl)Cyclobutan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutane scaffold with a difluoromethyl substituent. This compound is valued for its role in modulating the physicochemical and metabolic properties of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting challenging disease areas. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates in medicinal chemistry.
• Kinase Inhibitor Development: Used in the research and production of targeted cancer therapies and other kinase-related treatments.
• Metabolic Property Modulation: The difluoromethyl group is employed to fine-tune the lipophilicity, metabolic stability, and bioavailability of lead compounds.
• Agrochemical Research: Serves as a precursor in the development of new-generation pesticides and herbicides with improved efficacy.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	3-(Difluoromethyl)Cyclobutan-1-Amine Hydrochloride
CAS No.	1803586-55-1
Molecular Formula	C5H10ClF2N
Molecular Weight	157.59 g/mol
Synonyms	3-(Difluoromethyl)cyclobutan-1-amine hydrochloride; 3-(Difluoromethyl)cyclobutanamine hydrochloride; 1-Amino-3-(difluoromethyl)cyclobutane hydrochloride; Cyclobutanamine, 3-(difluoromethyl)-, hydrochloride (1:1); 1803586-55-1
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Cyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.