Description

2H-Pyran, 2-[2-[2-[2-(2-Bromoethoxy)Ethoxy]Ethoxy]Ethoxy]Tetrahydro- is a specialized bromo-terminated tetraethylene glycol derivative, serving as a crucial bifunctional linker and building block in advanced organic synthesis. Its core value lies in its unique structure, which combines a reactive bromoalkyl end for alkylation or nucleophilic substitution with a polyether chain that imparts solubility and flexibility. This compound is essential for researchers and manufacturers in the pharmaceutical, materials science, and biotechnology sectors who require precise molecular scaffolds for creating complex polymers, dendrimers, prodrugs, and surface-modifying agents.

Application

• Pharmaceutical Intermediate: Used in the synthesis of prodrugs, drug conjugates, and targeted delivery systems where a hydrophilic PEG-like spacer is required.
• Polymer & Dendrimer Synthesis: Acts as a key monomer or cross-linking agent for creating functionalized polyethers, star polymers, and dendritic architectures.
• Surface Functionalization: Employed to modify surfaces (e.g., nanoparticles, chips, sensors) by introducing reactive bromo groups for subsequent bioconjugation or polymer grafting.
• Ligand & Catalyst Tethering: Useful for attaching ligands, catalysts, or fluorescent tags to solid supports or macromolecules via its reactive termini.
• Material Science Research: Serves as a building block for developing novel non-ionic surfactants, hydrogels, and stimuli-responsive materials.
• Bioconjugation Chemistry: Facilitates the covalent attachment of biomolecules (peptides, oligonucleotides) through its alkylating bromo group.

Basic Information

Product Name	2H-Pyran, 2-[2-[2-[2-(2-Bromoethoxy)Ethoxy]Ethoxy]Ethoxy]Tetrahydro-
CAS No.	1803547-60-5
Molecular Formula	C15H29BrO6
Molecular Weight	385.30 g/mol
Synonyms	2-(2-(2-(2-(2-Bromoethoxy)ethoxy)ethoxy)ethoxy)tetrahydro-2H-pyran; THP-Protected Bromo Tetraethylene Glycol; Bromo-PEG4-THP; 2-Bromoethoxy-tetraethyleneglycol tetrahydropyranyl ether; 1-Bromo-2-[2-[2-[2-(tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy]ethoxy]ethane; Bromo-PEG4-THP Ether; THP-O-(CH2CH2O)4-CH2CH2Br
EINECS	Contact for details

Quality Control

Our 2H-Pyran, 2-[2-[2-[2-(2-Bromoethoxy)Ethoxy]Ethoxy]Ethoxy]Tetrahydro- is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H and ¹³C), HPLC, and GC analysis, to confirm identity, purity, and the absence of critical impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications for that lot. We support cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.