Description

Methyltetrazine-Propylamine Hcl Salt CAS NO 1802978-47-7 is a high-purity, functionalized tetrazine derivative used as a critical reagent in advanced bioconjugation and materials science. Its primary value lies in its exceptional reactivity in inverse electron-demand Diels-Alder (IEDDA) click chemistry, enabling rapid, bioorthogonal labeling and crosslinking under mild conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, diagnostic probe synthesis, and the creation of functional polymers and hydrogels.

Application

• Bioorthogonal Labeling in Drug Discovery: Site-specific conjugation of payloads (e.g., toxins, fluorophores, drugs) to antibodies, proteins, and other biologics for the development of Antibody-Drug Conjugates (ADCs) and targeted therapies.
• Diagnostic Probe & Imaging Agent Synthesis: Facile attachment of contrast agents (e.g., for PET, MRI) or fluorescent dyes to targeting molecules for in vitro and in vivo imaging applications.
• Materials Science & Surface Functionalization: Modification of nanoparticles, polymers, and solid surfaces to introduce click-reactive handles for creating smart materials, biosensors, and advanced coatings.
• Chemical Biology & Proteomics: Tagging and profiling of biomolecules in live cells for studying dynamic biological processes, protein-protein interactions, and enzyme activity.
• Precision Polymer Chemistry: Serving as a crosslinker or functional monomer in the synthesis of hydrogels and polymers with tailored degradation profiles and responsive properties.

Basic Information

Product Name	Methyltetrazine-Propylamine Hcl Salt
CAS No.	1802978-47-7
Molecular Formula	C7H13N5 • HCl
Molecular Weight	203.67 g/mol (Free base: 167.21 g/mol)
Synonyms	3-(3-Methyl-1,2,4,5-tetrazin-6-yl)propan-1-amine hydrochloride; 6-(3-Aminopropyl)-3-methyl-1,2,4,5-tetrazine hydrochloride; Methyl-Tetrazine-PEG3-Amine HCl; MeTz-PA HCl; Methyltetrazine-Propylamine Hydrochloride; TZ Amine HCl Salt; Click Chemistry Tetrazine Amine Reagent
EINECS	Contact for details

Quality Control

Every batch of Methyltetrazine-Propylamine Hcl Salt is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvent content. Our quality system is designed to support cGMP and ISO standards for research and pre-clinical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.