Description

(2S)-2-Benzyl-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid is a high-purity, non-natural amino acid derivative featuring a proline backbone with a benzyl side chain and an Fmoc-protected amine. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is essential for researchers and manufacturers in pharmaceutical development, particularly in creating novel therapeutic agents and advanced drug delivery systems.

Application

• Pharmaceutical Intermediates: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for metabolic and neurological disorders.
• Peptide Synthesis: Serves as a protected amino acid building block in solid-phase and solution-phase peptide synthesis (SPPS) for constructing custom peptide sequences.
• Protease Inhibitor Development: Used in the design and synthesis of potent inhibitors targeting specific proteases due to its proline-like structure.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Peptidomimetic Drug Discovery: Integral for creating stable, bioavailable peptidomimetics that mimic natural peptides for therapeutic use.
• Bioconjugation: The Fmoc protecting group allows for selective deprotection, making it useful in linker chemistry for antibody-drug conjugates (ADCs) and other bioconjugates.

Basic Information

Item	Details
Product Name	(2S)-2-Benzyl-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid
CAS No.	1802938-33-5
Molecular Formula	C27H25NO4
Molecular Weight	427.49 g/mol
Synonyms	Fmoc-(S)-2-Benzylproline; (S)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)-2-benzylpyrrolidine-2-carboxylic acid; Fmoc-2-Bzl-Pro-OH; Fmoc-S-2-Benzylproline; N-α-Fmoc-(2S)-2-benzylproline; N-Fmoc-trans-4-hydroxy-L-proline benzyl ester (related); 1-Fmoc-2-benzyl-L-proline; L-Proline, 1-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-(phenylmethyl)-, (2S)-
EINECS	Contact for details

Quality Control

Our (2S)-2-Benzyl-1-{[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Pyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.