Description

2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, (3S,4S)- is a high-purity, stereochemically defined spirocyclic amine building block of significant interest in advanced organic synthesis. Its unique rigid, three-dimensional structure makes it a valuable scaffold for medicinal chemistry, particularly in the development of novel pharmaceuticals targeting the central nervous system and other therapeutic areas. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in neurological and psychiatric drug candidates.
• Medicinal Chemistry Research: Used as a privileged scaffold in fragment-based drug design and lead optimization to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for potential clinical trial materials.
• Chemical Biology Probes: Utilized in the construction of molecular probes to study enzyme function and receptor-ligand interactions due to its spirocyclic constraint.
• Asymmetric Synthesis: Employed as a chiral auxiliary or template in stereoselective synthesis to induce enantioselectivity in target molecules.

Basic Information

Product Name	2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, (3S,4S)-
CAS No.	1801767-25-8
Molecular Formula	C9H18N2O
Molecular Weight	170.25 g/mol
Synonyms	(3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine; (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine; 2-Oxa-8-azaspiro[4.5]decan-4-amine, 3-methyl-, (3S,4S)-; (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine hydrochloride (salt form); 8-Azaspiro[4.5]decan-4-amine, 2-oxa-3-methyl-, (3S,4S)-; Spirocyclic amine building block; Chiral spirocyclic amine.
EINECS	Contact for details

Quality Control

Our 2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, (3S,4S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.