Description

2-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-[[(R)-(1,1-Dimethylethyl)Sulfinyl]Amino]-, 1,1-Dimethylethyl Ester, (4S)- is a high-purity, stereochemically defined advanced pharmaceutical intermediate (API intermediate) featuring a unique spirocyclic and sulfinyl-protected amino acid structure. This compound is critical for the synthesis of complex, biologically active molecules, offering precise chirality control essential for modern drug development. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel therapeutics, particularly in areas requiring sophisticated molecular scaffolds.

Application

• Key Intermediate in Pharmaceutical Synthesis: Serves as a crucial building block for the development of new active pharmaceutical ingredients (APIs), especially those targeting the central nervous system and other therapeutic areas.
• Chiral Auxiliary and Ligand Precursor: The defined stereochemistry at multiple centers makes it valuable for asymmetric synthesis and as a precursor for chiral catalysts or ligands.
• Peptidomimetic and Protease Inhibitor Research: Its spirocyclic and amino acid-like structure is ideal for constructing peptidomimetics and inhibitors for enzymes like proteases.
• Medicinal Chemistry and Drug Discovery: Used extensively in medicinal chemistry programs for lead optimization and structure-activity relationship (SAR) studies to improve drug potency and selectivity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the custom synthesis of candidate drugs under cGMP conditions.
• Academic and Industrial R&D: Employed in research laboratories for exploring new synthetic methodologies and novel chemical entities.

Basic Information

Product Name	2-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-[[(R)-(1,1-Dimethylethyl)Sulfinyl]Amino]-, 1,1-Dimethylethyl Ester, (4S)-
CAS No.	1801766-69-7
Molecular Formula	C17H31NO4S
Molecular Weight	345.50 g/mol
Synonyms	(4S)-4-[[(R)-(tert-Butylsulfinyl)amino]-2-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; tert-Butyl (4S)-4-[[(R)-tert-butylsulfinyl]amino]-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; (4S)-tert-Butyl 4-(((R)-tert-butylsulfinyl)amino)-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 4-[[(1,1-dimethylethyl)sulfinyl]amino]-, 1,1-dimethylethyl ester, (4S)-; Spirocyclic sulfinamide ester; Advanced API Intermediate 1801766-69-7.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and reliability for critical pharmaceutical applications. Quality is verified through comprehensive analytical techniques including HPLC, GC, NMR, and chiral analysis to confirm identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory submissions. Specifications can be developed to meet specific cGMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.