Description

2-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Oxo-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and oxazolidinone-like scaffold. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of novel drug candidates with potential activity in central nervous system and anti-infective therapeutic areas. Pharmaceutical R&D laboratories and fine chemical manufacturers need this precise intermediate to accelerate their discovery pipelines and develop next-generation active pharmaceutical ingredients (APIs). Its defined structure is essential for ensuring the reproducibility and efficacy of final drug molecules.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new chemical entities (NCEs), particularly for complex heterocyclic targets.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies to explore novel pharmacophores containing spirocyclic and lactam functionalities.
• API Synthesis: A crucial precursor in the multi-step synthesis of potential active pharmaceutical ingredients, especially those targeting neurological pathways.
• Chemical Biology Probe Development: Employed in the creation of specialized molecular tools for studying enzyme inhibition and receptor binding.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects requiring high-fidelity intermediates.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Oxo-, 1,1-Dimethylethyl Ester
CAS No.	1801766-68-6
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	tert-Butyl 4-oxo-2-oxa-8-azaspiro[4.5]decane-8-carboxylate; 8-(tert-Butoxycarbonyl)-4-oxo-2-oxa-8-azaspiro[4.5]decane; 2-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 4-oxo-, 1,1-dimethylethyl ester; Boc-Protected 4-Oxo-2-oxa-8-azaspiro[4.5]decane; Spirocyclic Oxazolidinone tert-Butyl Ester; 1801766-68-6; tert-Butyl 4-oxo-2,8-dioxa-5-azaspiro[4.5]decane-5-carboxylate (alternative representation)
EINECS	Contact for details

Quality Control

Our 2-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylic Acid, 4-Oxo-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring suitability for use in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.