Description

7-Bromo-6-Fluoro-3H-Quinazolin-4-One is a high-purity, advanced pharmaceutical intermediate with a distinct halogenated quinazolinone core structure. This compound is valued for its role as a critical building block in the synthesis of novel, targeted small-molecule therapeutics. It is primarily required by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for drug discovery programs, particularly those focused on kinase inhibitors and other biologically active agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Drug Discovery Scaffold: Serves as a core structural motif for constructing compound libraries in high-throughput screening (HTS) campaigns.
• Medicinal Chemistry Research: Used to explore structure-activity relationships (SAR) by modifying the quinazolinone core for enhanced potency and selectivity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Biochemical Probe Development: Utilized to create tool compounds for studying specific enzyme functions and signaling pathways.

Basic Information

Product Name	7-Bromo-6-Fluoro-3H-Quinazolin-4-One
CAS No.	1800261-92-0
Molecular Formula	C8H4BrFN2O
Molecular Weight	243.04 g/mol
Synonyms	7-Bromo-6-fluoro-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 7-bromo-6-fluoro-; 7-Bromo-6-fluoroquinazolin-4(3H)-one; 1800261-92-0; 7-Br-6-F-quinazolin-4-one; 6-Fluoro-7-bromo-3H-quinazolin-4-one
EINECS	Contact for details

Quality Control

Every batch of 7-Bromo-6-Fluoro-3H-Quinazolin-4-One is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.