Description

L-Proline, 3-Ethyl-4-Hydroxy-, Methyl Ester, (3S,4R)-, 4-Methylbenzenesulfonate (1:1) is a high-purity, non-natural amino acid derivative salt, specifically designed for advanced pharmaceutical and fine chemical synthesis. This compound is a critical chiral building block, valued for its defined stereochemistry at the 3S and 4R positions, which is essential for imparting specific biological activity and conformational properties in target molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical industry for the development of novel active pharmaceutical ingredients (APIs), particularly in peptide mimetics and protease inhibitor research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel Active Pharmaceutical Ingredients (APIs), especially for metabolic and cardiovascular diseases.
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and mimetics to enhance metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors for enzymes like prolyl oligopeptidase and other serine proteases.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective organic synthesis to introduce the proline moiety with high enantiomeric purity.
• Biochemical Research: Used in academic and industrial research to study enzyme-substrate interactions and structure-activity relationships (SAR).
• Fine Chemical Production: Intermediate in the manufacture of specialized agrochemicals and advanced materials requiring specific stereochemical configurations.

Basic Information

Product Name	L-Proline, 3-Ethyl-4-Hydroxy-, Methyl Ester, (3S,4R)-, 4-Methylbenzenesulfonate (1:1)
CAS No.	1799733-43-9
Molecular Formula	C15H23NO6S
Molecular Weight	345.41 g/mol
Synonyms	(3S,4R)-3-Ethyl-4-hydroxy-L-proline methyl ester 4-methylbenzenesulfonate; (3S,4R)-3-Ethyl-4-hydroxy-L-proline methyl ester p-toluenesulfonate; Methyl (3S,4R)-3-ethyl-4-hydroxy-L-prolinate p-toluenesulfonate; (3S,4R)-3-Ethyl-4-hydroxy-L-proline methyl ester tosylate; L-Proline, 3-ethyl-4-hydroxy-, methyl ester, (3S,4R)-, 4-methylbenzenesulfonate; Tosic acid salt of (3S,4R)-3-Ethyl-4-hydroxy-L-proline methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) providing batch-specific data for identity, purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.