Description

2-(3-Iodo-1H-Indazol-5-Yl)Spiro[Cyclopropane-1,3'-Indolin]-2'-One is a sophisticated, high-purity organic compound featuring a unique spirocyclic indolinone scaffold fused with an iodinated indazole moiety. This complex heterocyclic structure makes it a critical intermediate for advanced research and development in medicinal chemistry. It is primarily sought after by pharmaceutical R&D teams and contract research organizations (CROs) focused on discovering novel small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel drug candidates, particularly in oncology and CNS disease research.
• Kinase Inhibitor Development: The spirocyclic and iodinated structure is valuable for creating potent and selective kinase inhibitors.
• Chemical Biology Probes: Used to develop molecular probes for studying enzyme function and cellular signaling pathways.
• Medicinal Chemistry SAR Studies: Enables structure-activity relationship (SAR) exploration to optimize the potency and selectivity of lead compounds.
• Library Synthesis for High-Throughput Screening: Employed in the construction of diverse compound libraries for biological screening against novel targets.
• Process Chemistry & Scale-Up: Used in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2-(3-Iodo-1H-Indazol-5-Yl)Spiro[Cyclopropane-1,3'-Indolin]-2'-One
CAS No.	1799434-54-0
Molecular Formula	C17H11IN3O
Molecular Weight	400.19 g/mol
Synonyms	2-(3-Iodo-1H-indazol-5-yl)spiro[cyclopropane-1,3'-indolin]-2'-one; 2-(3-Iodo-1H-indazol-5-yl)-1'H-spiro[cyclopropane-1,3'-indol]-2'(2H)-one; 1799434-54-0; Spiro[cyclopropane-1,3'-indolin]-2'-one, 2-(3-iodo-1H-indazol-5-yl)-; 2-(3-Iodo-1H-indazol-5-yl)-1'H-spiro[cyclopropane-1,3'-indole]-2'(2H)-one; 2-(3-Iodo-1H-indazol-5-yl)spiro[cyclopropane-1,3'-indole]-2'-one
EINECS	Contact for details

Quality Control

Our production of 2-(3-Iodo-1H-Indazol-5-Yl)Spiro[Cyclopropane-1,3'-Indolin]-2'-One adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization using HPLC, NMR, and LC-MS to ensure structural identity and high chemical purity. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting purity, assay, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.