Description

(R)-4-Aminopyrrolidin-2-One Hydrochloride is a high-purity chiral building block and intermediate of significant importance in modern pharmaceutical research and development. This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug molecules, particularly those targeting neurological and metabolic disorders.
• Medicinal Chemistry Research: Serves as a versatile building block for constructing novel chemical libraries and exploring structure-activity relationships (SAR).
• Process Chemistry & API Development: Used in route scouting, optimization, and scale-up for the commercial manufacturing of active pharmaceutical ingredients.
• Asymmetric Synthesis: Employed as a precursor or reagent in catalytic asymmetric reactions to introduce stereochemical complexity.
• Bioconjugation & Probe Development: Potential use in creating labeled compounds or probes for biochemical and pharmacological studies.
• Academic Research: Utilized in university and institutional labs for fundamental studies in organic synthesis and methodology development.

Basic Information

Product Name	(R)-4-Aminopyrrolidin-2-One Hydrochloride
CAS No.	1788058-41-2
Molecular Formula	C4H9N2O·HCl
Molecular Weight	136.59 g/mol
Synonyms	(R)-4-Amino-2-pyrrolidinone hydrochloride; (R)-4-Aminodihydro-2(3H)-furanone hydrochloride; (R)-4-Aminopyrrolidin-2-one HCl; (R)-2-Oxo-4-aminopyrrolidine hydrochloride; (R)-4-Amino-2-pyrrolidone hydrochloride; (R)-Aminopyrrolidinone hydrochloride; (R)-4-AP hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-4-Aminopyrrolidin-2-One Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including chiral purity verification, to meet the exacting standards required for pharmaceutical R&D. A Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.