Description

(1R,2R,4S)-Rel-7-Azabicyclo[2.2.1]Heptan-2-Ol is a high-purity, stereochemically defined bicyclic amine alcohol building block. This compound is valued for its rigid, three-dimensional scaffold which is crucial for imparting specific biological activity and metabolic stability in advanced pharmaceutical research. It serves as a critical chiral intermediate for medicinal chemists developing novel therapeutics, particularly in the areas of central nervous system (CNS) agents and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a constrained scaffold to explore structure-activity relationships (SAR) and to improve the potency and selectivity of drug candidates.
• Asymmetric Synthesis: Employed as a chiral auxiliary or ligand precursor in catalytic asymmetric transformations due to its defined stereocenters.
• Chemical Biology Probes: Incorporated into molecular probes for studying enzyme function and receptor interactions within biological systems.
• Peptidomimetics: Serves as a non-natural amino acid analog to create more stable and bioavailable peptide-like compounds.

Basic Information

Product Name	(1R,2R,4S)-Rel-7-Azabicyclo[2.2.1]Heptan-2-Ol
CAS No.	1788054-75-0
Molecular Formula	C6H11NO
Molecular Weight	113.16 g/mol
Synonyms	(1R,2R,4S)-7-Azabicyclo[2.2.1]heptan-2-ol; rel-(1R,2R,4S)-7-Azabicyclo[2.2.1]heptan-2-ol; endo-2-Hydroxy-7-azabicyclo[2.2.1]heptane; 7-Azanorbornan-2-ol; Bicyclic amine alcohol; 2-Azabicyclo[2.2.1]heptan-7-ol (related isomer); 2-Hydroxy-7-azabicyclo[2.2.1]heptane
EINECS	Contact for details

Quality Control

Our (1R,2R,4S)-Rel-7-Azabicyclo[2.2.1]Heptan-2-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure high chemical and stereochemical purity suitable for demanding research applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.