Description

tert-Butyl 4-(Benzoylamino)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-value, protected intermediate in organic synthesis, specifically designed for the construction of complex nitrogen-containing heterocycles. Its core value lies in providing a versatile and reactive scaffold for medicinal chemistry research and pharmaceutical development. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its modifiable dihydroisoquinoline core.
• Alkaloid Synthesis: Serves as a precursor in the synthetic pathways for complex tetrahydroisoquinoline and related natural product analogs.
• Chemical Biology Probes: Employed in the development of molecular probes and tool compounds for studying biological pathways and enzyme functions.
• Agrochemical Development: Acts as an intermediate in the research and development of new herbicides, fungicides, or insecticides.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring high-purity, advanced intermediates.

Basic Information

Product Name	tert-Butyl 4-(Benzoylamino)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	1785764-68-2
Molecular Formula	C21H24N2O3
Molecular Weight	352.43 g/mol
Synonyms	tert-Butyl 4-benzamido-3,4-dihydro-1H-isoquinoline-2-carboxylate; 2(1H)-Isoquinolinecarboxylic acid, 4-(benzoylamino)-3,4-dihydro-, 1,1-dimethylethyl ester; 4-(Benzoylamino)-3,4-dihydroisoquinoline-2(1H)-carboxylic acid tert-butyl ester; BOC-4-Benzamido-1,2,3,4-tetrahydroisoquinoline; N-Boc-4-benzamido-1,2,3,4-tetrahydroisoquinoline; 4-Benzamido-N-Boc-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(Benzoylamino)-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.