Description

5,5-Difluoro-2-Aza-Bicyclo[2.2.1]Heptane Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique, rigid bicyclic scaffold. This compound is valued for its role as a key building block in medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and binding affinity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new therapeutics, particularly in areas such as central nervous system (CNS) disorders and enzyme inhibition.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery programs, especially for probing new chemical space.
• Protease Inhibitor Development: Used in the design and synthesis of inhibitors targeting specific proteases due to its constrained geometry and fluorine atoms.
• Ligand Synthesis for CNS Targets: Employed in creating novel ligands for neurological targets, where the fluorine atoms can influence pharmacokinetic properties.
• Chemical Biology Probes: Acts as a core structure for developing molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization during the transition from laboratory-scale to pilot-plant production.

Basic Information

Product Name	5,5-Difluoro-2-Aza-Bicyclo[2.2.1]Heptane Hydrochloride
CAS No.	1783656-28-9
Molecular Formula	C6H9ClF2N
Molecular Weight	168.59 g/mol
Synonyms	5,5-Difluoro-2-azabicyclo[2.2.1]heptane hydrochloride; 2-Azabicyclo[2.2.1]heptane, 5,5-difluoro-, hydrochloride; 5,5-Difluoro-2-azanorbornane hydrochloride; 5,5-Difluoro-1-azabicyclo[2.2.1]heptane hydrochloride (tautomer); Difluoroazanorbornane HCl; 1783656-28-9
EINECS	Contact for details

Quality Control

Our 5,5-Difluoro-2-Aza-Bicyclo[2.2.1]Heptane Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.