Description

[1-(Trifluoromethyl)Cyclopropyl]Methanamine Hydrochloride is a high-value, synthetically versatile building block featuring a cyclopropyl ring and a trifluoromethyl group, which are key motifs for modulating the physicochemical and metabolic properties of bioactive molecules. This compound is essential for medicinal chemistry research and development, particularly in the creation of novel small-molecule therapeutics. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for use as a critical intermediate in drug discovery programs targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), especially for candidates in oncology, CNS disorders, and antiviral research.
• Medicinal Chemistry: Used to introduce the metabolically stable cyclopropyl and lipophilic trifluoromethyl groups into lead compounds to optimize potency, selectivity, and pharmacokinetic profiles.
• Agrochemical Research: Serves as a precursor in the development of advanced pesticides and herbicides, where the unique fluorinated cyclopropyl structure can enhance biological activity.
• Material Science: Potential monomer or additive for creating specialty polymers with specific thermal or chemical resistance properties.
• Chemical Synthesis: Used in academic and industrial laboratories for methodological development and the construction of complex, fluorinated organic molecules.

Basic Information

Product Name	[1-(Trifluoromethyl)Cyclopropyl]Methanamine Hydrochloride
CAS No.	1783418-59-6
Molecular Formula	C5H9ClF3N
Molecular Weight	175.58 g/mol
Synonyms	(1-(Trifluoromethyl)cyclopropyl)methanamine hydrochloride; 1-(Trifluoromethyl)cyclopropanemethylamine HCl; (1-Trifluoromethyl-cyclopropyl)-methylamine hydrochloride; 1-(Aminomethyl)-2-(trifluoromethyl)cyclopropane hydrochloride; 2-(Trifluoromethyl)cyclopropanemethylamine hydrochloride; (1-Trifluoromethylcyclopropyl)methanamine HCl; Aminomethyl(trifluoromethyl)cyclopropane hydrochloride
EINECS	Contact for details

Quality Control

Our [1-(Trifluoromethyl)Cyclopropyl]Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (Titration)	95.0% - 105.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.