Description

6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One is a high-value spirocyclic indole derivative, a sophisticated chemical building block prized for its unique three-dimensional structure. This compound is critical for medicinal chemistry research and the development of novel therapeutic agents, particularly in central nervous system (CNS) and oncology targets. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and advanced contract research organizations (CROs) for lead optimization and scaffold diversification.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel small-molecule drugs targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a privileged scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a component in the design of heterobifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Employed in the construction of potential kinase inhibitors due to the spirocyclic framework's ability to modulate selectivity and potency.
• Chemical Biology Probes: Acts as a core structure for creating tool compounds to study biological processes and validate novel drug targets.
• Contract Manufacturing: Supplied to CDMOs for the cGMP production of active pharmaceutical ingredients (APIs) in clinical trial and commercial stages.

Basic Information

Product Name	6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One
CAS No.	1782634-38-1
Molecular Formula	C11H11ClN2O
Molecular Weight	222.67 g/mol
Synonyms	6-Chloro-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-2-one; 6-Chloro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]; 6-Chloro-2,3-dihydrospiro[1H-indole-3,3'-pyrrolidin]-2-one; 6-Chlorospiro[indoline-3,3'-pyrrolidin]-2-one; Spiro[indoline-3,3'-pyrrolidine]-2-one, 6-chloro-; 1782634-38-1; 6-Chloro-1,2-dihydrospiro[indole-3,3'-pyrrolidin]-2-one hydrochloride (salt form).
EINECS	Contact for details

Quality Control

Our 6-Chloro-1,2-Dihydrospiro[Indole-3,3'-Pyrrolidin]-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with client specifications and supporting regulatory filings for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.