Description

tert-Butyl 4-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is a high-value, protected spirocyclic building block of significant interest in advanced organic synthesis. This compound matters as a key intermediate for constructing complex molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Spirocyclic Compound Synthesis: Serves as a versatile precursor for the construction of complex spiroheterocyclic frameworks, which are privileged structures in drug discovery.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Agrochemical Research: Used as an intermediate in the development of new pesticides and herbicides with novel modes of action.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	tert-Butyl 4-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate
CAS No.	1782622-45-0
Molecular Formula	C13H21NO4
Molecular Weight	255.31 g/mol
Synonyms	8-Boc-4-oxo-1-oxa-8-azaspiro[4.5]decane; tert-Butyl 4-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate; 1-Oxa-8-azaspiro[4.5]decane-4-one, 8-(1,1-dimethylethyl) ester; Boc-1-oxa-8-azaspiro[4.5]decan-4-one; 4-Oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Oxo-1-Oxa-8-Azaspiro[4.5]Decane-8-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support regulatory filings, and we can supply material suitable for use under cGMP guidelines for advanced clinical-stage projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area %)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.