Description

(3Ar,6As)-Rel-5,5-Difluorooctahydrocyclopenta[C]Pyrrole Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique, stereochemically defined bicyclic structure with strategic fluorine substitution. This compound is critical for medicinal chemistry research and development, offering a valuable scaffold for modulating the pharmacokinetic and binding properties of novel drug candidates. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of complex, bioactive molecules, particularly in the areas of central nervous system (CNS) and metabolic disease therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the multi-step synthesis of novel active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Protease Inhibitor Development: The difluorinated cyclopentapyrrolidine structure is relevant for designing inhibitors of various enzymatic targets.
• Preclinical Candidate Synthesis: Employed in the gram-to-kilogram scale production of compounds for advanced biological testing and toxicology studies.
• Chemical Biology Probes: Useful for creating specialized molecular tools to study biological pathways and target engagement.

Basic Information

Product Name	(3Ar,6As)-Rel-5,5-Difluorooctahydrocyclopenta[C]Pyrrole Hydrochloride
CAS No.	1782456-99-8
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	rel-(3aR,6aS)-5,5-Difluorooctahydrocyclopenta[c]pyrrole hydrochloride; (3aR,6aS)-5,5-Difluorooctahydro-1H-cyclopenta[c]pyrrole hydrochloride; 5,5-Difluorooctahydrocyclopenta[c]pyrrole HCl (rel-(3aR,6aS)-form); Octahydrocyclopenta[c]pyrrole, 5,5-difluoro-, hydrochloride, rel-(3aR,6aS)-; Bicyclo[3.3.0]octane-based difluorinated pyrrolidine HCl
EINECS	Contact for details

Quality Control

Every batch of (3Ar,6As)-Rel-5,5-Difluorooctahydrocyclopenta[C]Pyrrole Hydrochloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency, supporting cGMP (current Good Manufacturing Practice) standards for advanced intermediates. A detailed Certificate of Analysis (COA) including chiral purity, assay, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.