Description

4-Pyridinecarboxylic Acid, 2-(1-Fluoro-1-Methylethyl)- is a high-value, fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique structural motif, combining a carboxylic acid handle with a sterically hindered, fluorine-bearing alkyl group, enabling precise molecular modifications. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by specialty chemical manufacturers producing advanced materials and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated, lipophilic motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the fluorinated pyridine core can enhance biological activity and environmental persistence profiles.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized chelating ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced organic materials with tailored electronic or surface properties.
• Chemical Biology Probes: Useful for creating fluorinated analogs of bioactive molecules to study enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	4-Pyridinecarboxylic Acid, 2-(1-Fluoro-1-Methylethyl)-
CAS No.	1782433-31-1
Molecular Formula	C9H10FNO2
Molecular Weight	183.18 g/mol
Synonyms	2-(1-Fluoro-1-methylethyl)isonicotinic acid; 2-(1-Fluoro-1-methylethyl)-4-pyridinecarboxylic acid; 2-(2-Fluoropropan-2-yl)isonicotinic acid; 2-(α-Fluoroisopropyl)isonicotinic acid; 4-Carboxy-2-(1-fluoro-1-methylethyl)pyridine; Isonicotinic acid, 2-(1-fluoro-1-methylethyl)-; 2-(1-Fluoro-1-methylethyl)pyridine-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 4-Pyridinecarboxylic Acid, 2-(1-Fluoro-1-Methylethyl)- adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.