Description

2-(2,2-Difluoroethoxy)Ethan-1-Amine Hydrochloride is a high-purity organic salt compound, specifically a hydrochloride salt of a difluoroethoxy-substituted amine. This compound is valued as a critical building block (synthon) in advanced organic synthesis, particularly for introducing functionalized amine groups into complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments engaged in the development of pharmaceuticals and agrochemicals, where its unique fluorine-containing side chain can impart desirable metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the difluoroethoxy moiety can enhance lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a functionalized amine ligand for constructing metal-organic complexes and catalysts used in asymmetric synthesis.
• Peptide Mimetics and Bioconjugation: Employed to incorporate fluorine tags or amine-reactive handles into peptides and biomolecules for drug discovery and diagnostic applications.
• Material Science Research: Acts as a monomer or modifying agent in the development of specialty polymers and functional materials with tailored surface properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function and biological pathways in academic and industrial research settings.

Basic Information

Product Name	2-(2,2-Difluoroethoxy)Ethan-1-Amine Hydrochloride
CAS No.	1782326-65-1
Molecular Formula	C4H10ClF2NO
Molecular Weight	161.58 g/mol
Synonyms	2-(2,2-Difluoroethoxy)ethylamine hydrochloride; 1-Amino-2-(2,2-difluoroethoxy)ethane hydrochloride; 2-(2,2-Difluoroethoxy)ethanamine HCl; N-(2-(2,2-Difluoroethoxy)ethyl)amine hydrochloride; 2,2-Difluoroethoxyethylamine hydrochloride; Ethanol, 2-(2,2-difluoroethoxy)-, amine hydrochloride; Aminoethoxy difluoroethane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(2,2-Difluoroethoxy)Ethan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and physical characteristics. Our quality commitment supports applications requiring research and development grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.