Description

3-Fluoro-1-Methylcyclobutan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate and building block. This compound is valued for its unique cyclobutane scaffold and fluorine substitution, which are critical for modulating the biological activity, metabolic stability, and physicochemical properties of novel drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new therapeutic agents, particularly in areas requiring structurally constrained amine motifs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs) and preclinical candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce fluorine and amine functionalities.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation pesticides and herbicides.
• Ligand and Catalyst Synthesis: Employed in the preparation of specialized ligands for asymmetric catalysis and metal complexes.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke chemical synthesis.

Basic Information

Product Name	3-Fluoro-1-Methylcyclobutan-1-Amine Hydrochloride
CAS No.	1781122-54-0
Molecular Formula	C6H13ClFN
Molecular Weight	153.63 g/mol
Synonyms	1-Amino-3-fluoro-1-methylcyclobutane hydrochloride; 1-Methyl-3-fluorocyclobutan-1-amine hydrochloride; 3-Fluoro-1-methylcyclobutanamine hydrochloride; 3-Fluoro-1-methyl-1-aminocyclobutane HCl; 1-Methyl-3-fluorocyclobutylamine hydrochloride; (3-Fluoro-1-methylcyclobutyl)amine hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Fluoro-1-Methylcyclobutan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.