Description

2-(Difluoromethyl)Pyrrolidine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a difluoromethylated pyrrolidine scaffold. This compound is valued for its role in modulating the physicochemical and metabolic properties of target molecules, making it a critical building block in modern drug discovery. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization, leveraging the fluorine atoms to enhance potency and bioavailability.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for preclinical and clinical trial material production.
• Protease Inhibitor Synthesis: Employed in the construction of peptidomimetic frameworks for inhibitors of various proteases, where the pyrrolidine ring acts as a proline surrogate.
• Agrochemical Research: Potential application in the development of novel agrochemicals, where the difluoromethyl group can improve stability and biological activity.

Basic Information

Product Name	2-(Difluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1781041-85-7
Molecular Formula	C5H10F2N•HCl
Molecular Weight	157.60 (Free base) / 194.06 (HCl salt)
Synonyms	2-(Difluoromethyl)pyrrolidine HCl; Pyrrolidine, 2-(difluoromethyl)-, hydrochloride; 2-(Difluoromethyl)-1-azacyclopentane hydrochloride; 2-(Difluoromethyl)azolidine hydrochloride; 1781041-85-7; (2R)-2-(Difluoromethyl)pyrrolidine hydrochloride (for enantiopure form); (2S)-2-(Difluoromethyl)pyrrolidine hydrochloride (for enantiopure form)
EINECS	Contact for details

Quality Control

Our 2-(Difluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.