Description

2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1) is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic and difluorinated structure. This compound is valued for its role in modulating the physicochemical and metabolic properties of active molecules, making it a critical building block in modern drug discovery. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel therapeutic candidates, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in CNS and oncology drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce conformational constraint and improve metabolic stability.
• Agrochemical Synthesis: Serves as a precursor in the development of new pesticides and herbicides, leveraging the fluorine atoms for enhanced bioactivity.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological targets and pathways.
• Ligand and Catalyst Development: Acts as a sophisticated scaffold for creating novel ligands and organocatalysts in asymmetric synthesis.

Basic Information

Product Name	2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1)
CAS No.	1780964-59-1
Molecular Formula	C9H16ClF2N
Molecular Weight	211.68 g/mol
Synonyms	8,8-Difluoro-2-azaspiro[4.5]decan-2-ium chloride; 2-Azaspiro[4.5]decane, 8,8-difluoro-, hydrochloride; 8,8-Difluoro-2-azaspiro[4.5]decane hydrochloride; 2-Azaspiro[4.5]decane, 8,8-difluoro-, monohydrochloride; 8,8-Difluoro-2-azaspiro[4.5]decan-2-ium chloride (1:1); Difluorinated azaspirodecane HCl salt; Spirocyclic amine hydrochloride derivative
EINECS	Contact for details

Quality Control

Our 2-Azaspiro[4.5]Decane, 8,8-Difluoro-, Hydrochloride (1:1) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.