Description

3-(4-Bromophenyl)-3-Fluoro-Azetidine Hcl is a high-value, fluorinated azetidine building block essential for modern pharmaceutical and agrochemical research. Its unique structure, featuring both a bromophenyl substituent and a fluorine atom on the azetidine ring, makes it a critical intermediate for constructing novel bioactive molecules. This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical industry for the synthesis of potential drug candidates, particularly in the areas of central nervous system (CNS) and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new active pharmaceutical ingredients (APIs), especially in CNS-targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce fluorine and azetidine motifs for improved metabolic stability and binding affinity.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Chemical Biology Probes: Employed in the synthesis of tool compounds for investigating biological pathways and target validation.
• Process Chemistry & Scale-up: Used in route scouting and optimization for the commercial-scale production of fluorinated compounds.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specialized fluorinated heterocycles.

Basic Information

Product Name	3-(4-Bromophenyl)-3-Fluoro-Azetidine Hcl
CAS No.	1780825-67-3
Molecular Formula	C9H9BrClFN
Molecular Weight	266.53 g/mol
Synonyms	3-(4-Bromophenyl)-3-fluoroazetidine hydrochloride; 3-Fluoro-3-(4-bromophenyl)azetidine HCl; 3-(p-Bromophenyl)-3-fluoroazetidine hydrochloride; Azetidine, 3-(4-bromophenyl)-3-fluoro-, hydrochloride (1:1); 1-(4-Bromophenyl)-3-fluoroazetidine hydrochloride; 3-(4-Bromophenyl)-3-fluoro-azetidine HCl salt
EINECS	Contact for details

Quality Control

Our 3-(4-Bromophenyl)-3-Fluoro-Azetidine Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.