Description

(4,4-Difluorotetrahydro-2H-Pyran-3-Yl)Methanamine is a high-purity fluorinated heterocyclic amine building block of significant interest in modern synthetic chemistry. Its core value lies in its unique molecular scaffold, which combines a difluorinated tetrahydropyran ring with a primary amine functional group, enabling precise structural modifications for advanced material and pharmaceutical development. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluorinated moiety can enhance bioavailability and stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the amine handle for complexation.
• Material Science Research: Incorporated into polymers or advanced organic frameworks to impart specific electronic or physical properties derived from the fluorine atoms and heterocyclic structure.
• Chemical Biology Probe Synthesis: Utilized as a building block for creating molecular probes and tool compounds to study biological pathways and protein function.

Basic Information

Product Name	(4,4-Difluorotetrahydro-2H-Pyran-3-Yl)Methanamine
CAS No.	1780779-29-4
Molecular Formula	C6H11F2NO
Molecular Weight	151.16 g/mol
Synonyms	3-(Aminomethyl)-4,4-difluorotetrahydro-2H-pyran; 4,4-Difluoro-3-(aminomethyl)tetrahydro-2H-pyran; (4,4-Difluorotetrahydro-2H-pyran-3-yl)methanamine; 3-(Aminomethyl)-4,4-difluorotetrahydropyran; 4,4-Difluoro-3-pyranmethanamine, tetrahydro-; 1780779-29-4; (4,4-Difluoro-tetrahydro-pyran-3-yl)-methylamine
EINECS	Contact for details

Quality Control

Our (4,4-Difluorotetrahydro-2H-Pyran-3-Yl)Methanamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent quality suitable for research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.