Description

4-Bromo-5-Fluoro-2-Methoxy-Benzoic Acid is a high-purity, multi-functional aromatic building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, offering precise bromo and fluoro substitution patterns for structure-activity relationship (SAR) studies. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogenated benzoic acid scaffold imparts specific biological activity.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for advanced electronic materials, contributing to the molecular design of charge-transport layers and emissive compounds.
• Chemical Biology & Proteomics: Employed as a derivatization agent or a tagged scaffold for probing enzyme activity and protein-ligand interactions.
• Academic & Contract Research: Essential for academic research and CROs (Contract Research Organizations) conducting exploratory organic synthesis and method development.
• Custom Synthesis & Scale-Up: A starting point for custom synthesis projects, offering scalability from gram to multi-kilogram quantities under cGMP conditions where required.

Basic Information

Product Name	4-Bromo-5-Fluoro-2-Methoxy-Benzoic Acid
CAS No.	1780187-45-2
Molecular Formula	C8H6BrFO3
Molecular Weight	249.04 g/mol
Synonyms	2-Methoxy-4-bromo-5-fluorobenzoic acid; 5-Fluoro-4-bromo-2-methoxybenzoic acid; Benzoic acid, 4-bromo-5-fluoro-2-methoxy-; 4-Bromo-5-fluoro-2-methoxybenzoic acid; 1780187-45-2
EINECS	Contact for details

Quality Control

Our production of 4-Bromo-5-Fluoro-2-Methoxy-Benzoic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All materials are characterized by advanced analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We support development under quality systems aligned with ICH guidelines and can supply material suitable for cGMP manufacturing upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.