Description

1-Bromo-3-Chloro-5-Methanesulfonylbenzene is a high-purity, multi-functional aromatic building block designed for advanced organic synthesis. This compound matters for its unique substitution pattern, offering three distinct reactive sites—bromine, chlorine, and a methanesulfonyl group—that enable precise, sequential functionalization. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing activity-based probes (ABPs) and molecular tags due to its reactive handles.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions, facilitated by the bromo and chloro substituents.
• Sulfone Chemistry Exploration: The methanesulfonyl group acts as a strong electron-withdrawing group and can participate in further transformations like nucleophilic aromatic substitution.

Basic Information

Product Name	1-Bromo-3-Chloro-5-Methanesulfonylbenzene
CAS No.	1779769-70-8
Molecular Formula	C7H6BrClO2S
Molecular Weight	269.54 g/mol
Synonyms	3-Bromo-5-Chlorophenyl Methyl Sulfone; 5-Bromo-3-Chlorophenyl Methyl Sulfone; 1-Bromo-3-chloro-5-(methylsulfonyl)benzene; Benzene, 1-bromo-3-chloro-5-(methylsulfonyl)-; Methyl 3-Bromo-5-Chlorophenyl Sulfone
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-Chloro-5-Methanesulfonylbenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.