Description

tert-Butyl 7-Bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate CAS NO 1779125-91-5 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for the synthesis of novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents, particularly in central nervous system (CNS) and oncology-related drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic structure can be utilized as a component in the design of heterobifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Serves as a core scaffold for the development of novel kinase inhibitors due to its privileged structure.
• Chemical Biology Probes: Employed in the creation of molecular probes to study biological processes and identify new drug targets.
• Custom Synthesis & Scale-Up: Available for custom synthesis projects from milligram to kilogram scale to support preclinical and early-phase clinical development.

Basic Information

Product Name	tert-Butyl 7-Bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate
CAS No.	1779125-91-5
Molecular Formula	C17H21BrN2O3
Molecular Weight	381.27 g/mol
Synonyms	1'-Boc-7-bromo-2-oxospiro[indoline-3,4'-piperidine]; 7-Bromo-1'-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,4'-piperidine]; tert-Butyl 7-bromo-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 7-Bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1'-(tert-Butoxycarbonyl)-7-bromospiro[indoline-3,4'-piperidin]-2-one; 7-Bromospiro[indoline-3,4'-piperidin]-2-one-1'-carboxylic acid tert-butyl ester; BOC-7-Bromo-2-oxospiro[indoline-3,4'-piperidine]; 1779125-91-5
EINECS	Contact for details

Quality Control

Our tert-Butyl 7-Bromo-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and stored away from direct light and moisture sources.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.